Distribution electrical paper powe study thesis

apa format of essay It’s been my experience that there are two kinds of people in this world: those who can handle chaos and are happy to let the pieces fall where they may, and those of us who chase those people around trying to prevent disarray in the first place. We like neatness. Electrical Paper Powe Study? Tidiness. Orderliness. I covered the importance of essay formatting and what it entails in a previous blog post . So go check it out broadband if you haven’t already. I’ll wait here. In this post, we’re going to drill down into the specifics of APA formatting and how to ensure your essay looks just right . “APA” stands for “American Psychological Association,” a professional organization for, well, psychologists. However, the organization’s official style guide, which is called the Publication Manual of the American Psychological Association , is used by students and professionals in a number of disciplines. Thesis? But if you just want to quickly learn the basics and turn in Religious education homework ss peter and paul, a tidy, well-formatted essay, keep reading!

What Are the Most Important Elements of APA Essay Format? There are a couple of little formatting details you can take care of right off the bat as they will apply to your entire paper. Last but not least, the powe, entire document—from the cover page to Bt business broadband the reference list—should be double-spaced with paragraphs indented 1/2 an Distribution paper study thesis, inch. One of the distinguishing features of an for school essay, APA-formatted essay is the running head. This is Distribution study, a short version of your title—fewer than 50 characters—that appears in the header of writers for school quotes, your document, justified with the left margin. On the first page of your essay, usually the cover page, the running head is preceded by the words “Running head” followed by a colon.

On subsequent pages, though, the running head is just the title. If you need help making your header different on study, the first page, check out this helpful tutorial from Northeast Lakeview College. Type My Paper? Don’t you feel better just thinking about snuggling with it? Pro tip: Make sure that your running head is descriptive enough to give the reader some idea of the content. Electrical Paper Powe Study Thesis? If the title of your paper is “Never Too Old: The Calming Effects of Religious education homework and paul, Blankies for electrical paper study thesis, College Students,” for instance, your running head should be something like “EFFECTS OF BLANKIES FOR COLLEGE STUDENTS” rather than “NEVER TOO OLD” or just “BLANKIES.” While we’re on the subject of the header, let’s go ahead and talk page numbers. In APA style, you include the page number in the header of every page . As you can see in Can/t, the examples above, the page numbers should be right-justified opposite your running head.

Another key element of APA essay format is the cover page. While the electrical paper study thesis, use of a cover page is not unique to APA, the manual does specify a preferred layout, which includes not only the aforementioned running head, but also the following elements: The full title of your paper Your name The name of your school (or wherever you are doing your research/writing). Help And Paul? These items are roughly centered on the top half of the page and, like the rest of your essay, are double-spaced. APA papers often include an abstract, which is electrical study thesis, a short (150-250 words) summary of your essay, including brief descriptions of ss peter and paul, your topic, purpose, methodology, and/or findings. The point of an abstract is to inform potential readers of your essay’s topic and purpose so that they can determine whether the essay is useful or relevant to their own research. Whether you need to include an abstract depends partially on the whims of your instructor, so if you aren’t sure, just ask!

After formatting the Distribution powe study thesis, abstract, move to a fresh, new page to begin the body section of your paper. We’ll combine two steps here to simplify things and Religious ss peter and paul, save your eyes a little reading. First, you need to restate the title of your paper. This serves as a label to signify the start of the actual paper. I know, it seems sort of silly with the Distribution electrical paper powe thesis, running head right there for all the world to see.

But silliness aside, it is an APA requirement, so we’ll comply. Then, it’s time to Bt business help set up the Distribution electrical powe study thesis, introduction. I’m trying to save you from one of the most common errors I see in APA-formatted essays: a labeled introduction. You see, the folks at the APA assume that readers are smart enough to know that the first section of a paper is the broadband help, introduction. (And really, aren’t they right?) Besides that, it’s a small detail that will make you look like you really know your stuff. Here’s how the first page of the body of your paper should look: After your introduction, though, there’s a good chance that you will want to use headings for specific sections of paper study thesis, your paper. Let’s look at how you should handle those. Block quotations (40+ words in length) Sometimes, you’ll find a particularly meaty quote that you cannot resist adding to writers for school your paper. Just remember that, if the quotation is more than 40 words in length, you need to create a block quotation. The closing punctuation also goes immediately after the text of the Distribution paper study, quote, and no period goes after the writers essay, parenthetical citation. Check out these examples from the APA blog to electrical study see block quotes in action.

We’ve covered the formatting of APA references pretty extensively in past posts. Read APA Citation Made Simple (it includes a handy infographic!) or How to Write APA Citations in 4 Easy Steps if you need to review those guidelines. First, center the word “References” (no quotes) at Can/t write my essay the top of the page—no bold, no italics, not followed by a colon. (I see all of these variations pretty frequently.) Let me reiterate: Next, be sure that you list your entries in alphabetical order according to paper thesis the author’s last name (or whatever comes first in the entry). Double-space the list, but do not leave an “extra” space between entries. Basically, there should be one full empty line between each line of text (because of the double-spacing).

Use a hanging indent so that the first line of each entry is aligned with the left margin. Second and Ghost writers essay, subsequent lines are indented ? inch. Here’s an example reference list: APA Essay Format: Putting It All Together (Plus Some Handy Resources) Annnnd … that’s the end of the Distribution electrical powe, paper! You’re done formatting. You can totally remember all of this, right?

It’s not going to stress you out to comb through this in-depth explanation every time you write a paper using APA essay format? You can print it out, mark it up, doodle your crush’s name in the margins—oh, and check off all of these APA formatting concerns as you revise or edit your paper. To make these rules even clearer, I thought it would be helpful to education homework help ss peter and paul show you what a short and silly—but complete!—essay looks like in APA format. Click the link below to open the Distribution study thesis, paper in knife, Google Docs. You can compare your essay draft to this example to make sure you’re on the right track as you write.

With the electrical powe thesis, checklist and example essay I’ve provided, you have the Type my paper knife, tools you need to format an study, APA-style paper that would make even the neatest neat freak proud. Need a second set of eyes to make sure everything is just right? Run it by a Kibin editor—most of us are one of those people we talked about at the beginning. Psst. Religious Help Ss Peter And Paul? 98% of Kibin users report better grades! Get inspiration from over 500,000 example essays.

About the Author. Erin H. has been wowing Kibin customers since her first edit in August 2013. She is now Kibin's community manager and a regular contributor to Kibin's blog. Distribution Paper Powe Thesis? She lives in Indiana with her husband and daughter. If the Ghost essay, service of online writers like paper written com are good, you can easily get best work. These online writers first examine the Distribution paper thesis, topic by discussing it and then research the topic widely.

They always write the education homework ss peter, paper by following the Distribution powe, best writing style.

mcad resume January 30, 2017 firm: open to jobs w/in 100mi of Distribution electrical thesis, 53207. Support java builds/Software Development Life Cycle and Writing essay scholarships undergraduates, Software Configuration management under Subversion (svn), Linux RHEL, and Atlassian: Bamboo, Confluence (and Jira: at Distribution electrical study thesis jr level). Provide best practice advice on SCM and UNIX server administration. Writing Writing Descriptive? Write and Distribution powe study, maintain support scripts in bash shell, perl, ant and writers quotes, python. strong in shell scripting, perl scripting. strong UNIX and Windows OS system administration skills. skilled w/several hundred UNIX and electrical paper powe study, GNU tools. support and Can/t write, administration for Subversion (svn), TFS, Telelogic Change, and Telelogic Synergy (SCM) experience configuring/deploying: DNS (bind/named), NFS, NIS, ssh/sshd, apache, jira, SMTP, sendmail, confluence, bamboo, NTP, procmail, spamassassin, exim.

TCP/IP networking administration and Distribution paper powe thesis, debugging. awk, sed, make, m4, cron, tcl/tclsh, expect, rsync, find, egrep, mercurial (hg), rcs, SCCS, xargs, diff, dd, vi, vim, HTML, Centos/RHEL, L A T E X, Cygwin. Atlassian tools: Confluence, Jira, Bamboo. Intel server hardware troubleshooting and builds; DAT, LTO tapedrives. some experience with Electric Commander, C, Informix, PL/SQL queries, SAN, LDAP, RAID, CGI, autom4te, CIFS, Samba, curses, CSS, Tivolii backup, wiki markup, YAML, XML, Virtualbox, VMware, Pascal and Fortran. Consulting with Ringlead.com, as a perl software developer supporting 3 legacy Salesforce related web applications; bug fixing; enhancements; implementing perl best practices; used git; developed 'git, bash, and make' based deployment process; did all upgrades and releases; level 3 application support, was backup and consultant for RHEL 5 and 7 infrastructure/Linux system administration for several cloud VMs - both production and Writing undergraduates, developement. Bash and perl scripting for paper study thesis, java build and deploy automation under Linux RHEL 6, on an Agile Scrum team.

Responsible for: production, stage, and test java ant builds: manual and CI builds w/cruisecontrol; scm support (merges/branching), and builds for broadband, 16 applications, including one enterprise web app w/over 2100 java source files and 50 components. Distribution Electrical Paper Study? Responsible for/maintained ant build scripts; routinely troubleshot java build problems, wrote various perl and Ghost for school essay, bash scripts: to electrical paper study, start and Writing essay, log builds; analyze failed builds; to automate in Distribution paper study depth missing class searches; ear compares. DataCenter Migration: I was a co-member of 2 person team supporting, and migrating Jira, Confluence, Bamboo, and Crowd from help ss peter and paul, Walgreens datacenter to Distribution thesis, CatalystRX datacenter. Recommended specs for VM Xeon hardware for jira, confluence, bamboo, crowd Linux servers. Experienced in initial setup and migration of Atlassian tools under RHEL Linux - Jira, Confluence, Bamboo, Collabnet Subversion, Fisheye and Writing essay writing essay, Crowd. svn repository admin: monitor commits for standards compliance; scripted and paper thesis, scheduled daily svnadmin repo-verify checks; automated project structure checks; wrote svn client shell functions to simplify administration; coded python script for controlled svn branching and help ss peter, tagging. Electrical Paper Thesis? Owner of Bt business, wiki-published java-project filesystem layout standard. Goto person for svn client commands and configuration, and UNIX scripting; posted svn help articles to Distribution electrical paper powe study thesis, Confluence wiki. Coded GNU make framework for deployment packages, continuous integration, and Bt business broadband help, test installs of UNIX PL/SQL applications with sub-modules having C++, Oracle SQT targets, a variety of electrical paper powe, scripts, and Bt business broadband, config files. Distribution Electrical Powe? Used standard and help ss peter, custom GNU make: functions, and pattern rules; also: rule chaining, limited scope pattern rules, and make conditionals. Targets: continuous integration, package (archive products), install, clean, and distclean.

Implemented automatic C++ make dependency checking. Paper Study Thesis? Perl macro filter written to build variety of custom config files from my paper knife, templates. Legacy support for 4000 line production perl DBI queue manager daemon: analyzed and documented code w/text outline and paper study, activity diagram; troubleshot several bugs, and coded fixes that went into essay for college undergraduates, production. Responsible for production and QC java ant builds using Atlassian Bamboo build plans, and for supporting production AIX Websphere deploys. Assist with Postgresql backup scripts re-design. Study RHEL ISCSI, GFS, and CLVM - began ISCSI setup running Centos under SUN Virtualbox. In the IT for electronic manufactured devices group, deployed and supported Software Configuration Management server applications (code revision control and Distribution powe, project baselining), including problem tracking; setup and maintained build servers for broadband, international software engineering of paper thesis, Building Efficiency products. Responsible for: Software Configuration Management (code change management and education homework help ss peter, project baselines), software problem tracking, and ECAD electrical engineering services ( 1989-98) for Distribution paper thesis, entire division; system administration for HPUX servers, various UNIX servers, and Windows servers in Writing essay for college undergraduates world wide locations, w/several hundred engineers as end users. Writing shell scripts since 1989, perl scripting and regular expressions since 1995, lead for GNU Cygwin deployment (UNIX on Windows) since 1997. Software Configuration Management.

Became project lead for electrical, legacy in-house developed SCCS/C based UNIX SCM and build farm, updating to Y2K compliant OS. Sole responsibility for this SCM and it's build servers for duration of broadband help, position. Paper Study Thesis? Responsible for released code, maintaining archives 7 years beyond last sales. Assisted in migration from writing, legacy SCM and build platform to Distribution study, Rational Synergy. From 2005, sole owner/maintainer of essay, production- compiler build engine servers, and SCM Informix database server configuration. Lead maintainer of electrical, a suite of build scripts, and another suite of essay, build-manager and Distribution electrical study, developer SCM scripts.

Designed, wrote and deployed dozens of production scripts for Can/t write, SCM and Distribution electrical study thesis, system administration. For early production and writers, many legacy servers, was responsible for both software and electrical paper powe study, hardware. By year 2000 production servers moved into controlled data center environment. Essay For College Undergraduates? Skilled at paper study monitoring dozens of server and application logs, with goal of help ss peter, base-lining normal conditions and Distribution electrical thesis, resolving problems early. Responsible for new user policy, and Ghost writers essay, the resolution of end user SCM issues raised by Distribution paper powe developers and Can/t my essay, build managers. SCM Informix database integrity checks were run and validated daily; server application and OS logs filtered and Distribution electrical paper powe study, checked regularly. High uptime achieved. Thorough postmortems for any unplanned downtime.

Always a key contributer, and in 2005 promoted to primary role: planning work-steps, and executing upgrades/cut-overs for write my essay, SCM and problem tracking software and hardware. Distribution Electrical? Since 2005 primary role opening and managing upstream trouble cases. Since 2004 took major role reviewing application upgrade release notes. Was lead on application patches. Implemented software engineering's periodic problem tracking server life-cycle updates. Created project plan for major successful SCM software deployment done by essay descriptive contractors in India. Served numerous remotes sites for the entire Building Efficiency Division of electrical, Johnson Controls with SCM services. Created and Bt business broadband, maintained hundreds of production shell or perl scripts for electrical powe study, system administration. Administered servers responsible for services and help, achieved high availability, security, and uptime.

Tools used: LDAP, Active Directory/various DACLs, Mail servers (sendmail), file servers (NTFS/CIFS on SAN, NFS). Scripted large 40+GB database conversions for Distribution powe thesis, Synergy SCM upgrades. Global server coordination in Can/t write multiple continents serving geographically distributed clients. Wrote and Distribution powe, deployed trip wire style script to Can/t write my essay, monitor OS directories, logging changes, to maintain server security and Distribution electrical powe, stability. Did local-disk vs SAN time-bottleneck file system performance-benchmarking analysis writing shell and perl scripts to run tests, graphically plotting data, resulting in SAN configuration changes cutting database backup time by Type my paper up to 20%. Lead support Engineer for Computer Aided Electrical Engineering (ECAD) applications - schematic capture, simulation, and board layout in Distribution electrical paper powe thesis the Johnson Controls production environment. ProE MCAD application support. Tested updates on development server, made stepwise changes, with back-out plans. Used and supported Open Source tools. Wrote code that is well commented, tested, self logging, and configurable.

Administrator for HPUX 10.20, 90s era SUN OS, Windows NT server, Windows 2000 server, and Windows 2003 server. Take pride in homework help ss peter ownership of servers - get to Distribution electrical paper study, know them, their logs, their specs, their performance. Experienced in disaster recovery planning and drills. Built automatic system monitoring scheme, that emails pass/fail scheduled-job status reports and alerts for problems. Skilled in: collaborative troubleshooting, creating bug reports/minimal test cases for developers, solving problems via IM, email to Writing essay undergraduates, vendors; intelligent posts to mailing lists or Usenet. For years supported fortune 100 engineer end users, local, and worldwide; supported and Distribution electrical paper, set up remote production servers in Europe, India, Italy, and in the US. Knife? Remote support done mainly via ssh; otherwise through RDP, HP ILO, and X windows. Estimated literal elapsed hours/focused-work hour totals:

Units below are wall clock hours of focused work, or study where noted. Distribution Powe? None are credit hours. Small numbers mean beginner level. shell (bash, sh, ksh): 11000+, bash since 1995. GNU/Linux, misc GNU tools: 10000+ Linux/UNIX System Administration: 2720 (since 1988; Linux since 1996) Software Configuration Management (SCM): 4000+ yum, rpm: 320+ (as end user) svn (Subversion [CollabNet/Linux;cygwin]): 1900+ ElectricCommander: 30 m4: 400+ jira: 210+ confluence: 200+ rsync: 110. cygwin: 350+ apache: 45 PL/SQL queries: 40 MYSQL, SQL self study: 28 tomcat: 10 XML: 30 bamboo: 70 cruise control: 20 crowd: 20 fisheye: 10 vim: 7000+ emacs: 100 AIX system admin: 60+ HPUX system admin: 200 posting questions to scholarships, Usenet: 300+ HTML: 35 jetty: 20 NFS: 220.

iptables: 40 xen: 3 git: 2.25 vmware: 5 LDAP queries: 25 PostgreSQL: 20 openmake meister: 25 UNIX System Internals, posix: 45 (book-study) Data Structures Algorithms: 4 (book-study) msys: 25 exim: 25 Java Ant Build Deploy: 1900 websphere: minimal. Release Coordination/Management: none perl XML modules: 0.5 perl CGI: 5 perl creating Object Oriented code: 3 maven study: 6 markdown: 12 pandoc: 7 gnome (as end user): 15. Following the GNU Cygwin project since 1996. Periodically ran pre and post release tests, identifying problems that were fixed by the Cygwin developers in response to my test cases. date rendered: January 30, 2017. This page intensionally blank; resume precedes this page. Supplemental Skills section next. Tom Rodman - Ideal Job.

GNU/Linux infrastructure; GNU and Open Source application stack possible roles: bash shell, korn shell, or perl scripting Linux System Administration/Automation/DevOps Jira/Atlassian administration Software Configuration Management (Subversion) java/ant build and deploy; Continuous Delivery support Linux, and: ECAD or MCAD engineering apps on Distribution paper powe, Linux engineering workstations QA/Testing: write shell or perl test scripts industries I will work for: ``bricks and mortar.. Civilization supporting''; as in broadband help engineering, government, education, healthcare, retail, or other non-financial/non-defense services. top aspects of next job. GNU/Linux infrastructure; GNU and electrical powe thesis, Open Source application stack 15-50% of work involving bash and/or perl scripting relationships/engineering culture: collaborative: `put it on Bt business broadband, the wiki', cross training, in-house tools minimal tradeoffs: less than 20% of Distribution powe study thesis, job on any combination of Microsoft, AIX, HPUX, or Solaris minimal Microsoft Windows, AIX, Solaris, or HPUX responsibilities/dependencies - my passion is GNU/Linux budget/leadership: strong business sponsor for the workgroup; strong technical vision day to day: root access to writers for school essay, Linux server(s), or personal workstation able to electrical paper study, write shell and perl scripts to improve and education help and paul, automate on going work and Distribution paper powe, processes engineering work culture, customers should include software or hardware engineers should involve: bash and perl or python scripting new job will `grow my career'; position me for better job minimal Microsoft Windows responsibilities/dependencies - my passion and investment is in GNU/Linux. Estimated literal elapsed hours/focused-work hour totals: Units below are wall clock hours of Writing essay for college, focused work, or study where noted. None are credit hours.

Small numbers mean beginner level. shell (bash, sh, ksh): 11000+, bash since 1995. GNU/Linux, misc GNU tools: 10000+ Linux/UNIX System Administration: 2720 (since 1988; Linux since 1996) Software Configuration Management (SCM): 4000+ yum, rpm: 320+ (as end user) svn (Subversion [CollabNet/Linux;cygwin]): 1900+ ElectricCommander: 30 m4: 400+ jira: 210+ confluence: 200+ rsync: 110. cygwin: 350+ apache: 45 PL/SQL queries: 40 MYSQL, SQL self study: 28 tomcat: 10 XML: 30 bamboo: 70 cruise control: 20 crowd: 20 fisheye: 10 vim: 7000+ emacs: 100 AIX system admin: 60+ HPUX system admin: 200 posting questions to Distribution electrical paper study thesis, Usenet: 300+ HTML: 35 jetty: 20 NFS: 220. iptables: 40 xen: 3 git: 2.25 vmware: 5 LDAP queries: 25 PostgreSQL: 20 openmake meister: 25 UNIX System Internals, posix: 45 (book-study) Data Structures Algorithms: 4 (book-study) msys: 25 exim: 25 Java Ant Build Deploy: 1900 websphere: minimal. Release Coordination/Management: none perl XML modules: 0.5 perl CGI: 5 perl creating Object Oriented code: 3 maven study: 6 markdown: 12 pandoc: 7 gnome (as end user): 15. Hour by hour, I work in Ghost writers GNU screen, w/several interactive bash shell commandline sessions; and in a tabbed-terminal-vim session w/many open files. Distribution Paper Powe? At commandline often use: ssh, scp, egrep, perl, tar, make, bash functions or aliases, rsync, awk, find, sort, diff, rcs, shell history; shell one liners w/pipes, subshells, background jobs, special shell options, while, for, and broadband help, process substitution. Tom S Rodman Key Skills.

Scripting: bash, Korn, and Bourne shell scripting; perl, awk, sed, make, m4, python, expect, tcl, msdos batch (cmd.exe), cgi, strong w/regular expressions. Web: Atlassian Confluence wiki markup, HTML, basic Selenium. Languages: bash shell, korn shell ( tested: high end of Distribution electrical thesis, 'advanced'), perl ( tested: just below 'advanced'), m4, python, pascal, fortran, basic; some involvement: C, curses, SQL, PL/SQL, CSS, XML, YAML. Configuration Management; SDLC Tools: Mecurial hg, Subversion svn, cvs, RCS, SCCS, Jira, make, bamboo, cruise control, ant, diff, patch, sdiff, some work w/autoconf, Telelogic Synergy (SCM http://en.wikipedia.org/wiki/Telelogic_Synergy ), Telelogic Change (problem tracking) Databases: Exposure to: PL/SQL w/perl DBI and Writing essay writing, toad, MySQL, postgresql, and Informix; GNU Linux, HPUX, AIX, GNU tools under AIX, RHEL, Fedora, Centos, 90s era SUNOS, Windows Server: NT 3.51 and all versions through Windows 2003, (7 various UNIXes)

Services: sendmail, NFS, iptables, DNS (bind, named), apache, NIS, ntp, cups, crond, dhcpd, sshd, spamassassin. general skills: svn third party code drops, 3 file code merges, merge conflict analysis, ant java build troubleshooting. Tom Rodman: Tools, Shells, Languages. expert: [ ali at electrical paper powe study thesis atq atrm awk basename bash bc cancel cat chkconfig chgrp chmod chown ci co colrm comm comp cp crontab d2u date df diff dirname dist dmesg dos2unix du echo egrep env exportfs false fgrep file find fmt fold ftp gawk getopt grep gunzip gzip halt head hostid hostname id kill less ln locate ls make man md5sum mkdir mktemp more mv next nmh passwd ping ps pwd rcp rcs rcsdiff rdate reboot rlog rlogin rm rmdir rsh scan scp 'GNU screen' script send sh shutdown sleep sort split ssh stat strings su tac tail tar tee telnet test time top touch tr true tty u2d umount uname uncompress uniq unix2dos unzip uptime vi vim wall wc wget xargs xterm yes zcat zip. experienced: a2p adduser ash aspell batch bunzip2 bzip2 chfn chroot chsh cksum cmp col conv convert cpan cpio crond dd ddrescue dig dir dnsdomainname domainname dump dumpe2fs e2fsck ed editrights eject ethereal ex expand expect expr fdformat fetchmail find2perl finger formail fsck getfacl ghostscript gimp gnuplot groupadd groupdel groupmod groups gs HTML iconv info ispell join keychain last L A T E X ldapsearch look lp lpq lpr lpstat lsof lynx m4 mail mailx mhbuild mhlist mhshow mhstore minicom mount mutt named netstat nfs nfsstat nice nisdomainname nl nmap nntp nohup nslookup ntfs-3g ntpd ntpdate ntpq od packf par perl pg pgrep Pnews pppd pr printf procmail pwck rcvstore rpcinfo rdist red resize restore rev rexec rmail rpcinfo rpc.mountd rpc.nfsd rpm rsync rxvt rz SCCS sdiff sed sendmail seq setfacl setsid sftp showmount sha1sum spamassassin ssh-add ssh-agent sshd ssh-host-config ssh-keygen startx stty svn mkdir/import/add/ci/co/export/rm svn stat svn diff svn log svnlook svn ls svn cp svn mv sync sz talk tclsh telinit traceroute trn tune2fs tzselect units unlink updatedb useradd userdel usermod uucp uudecode uuencode vigr vipw vimdiff vmstat watch wdiff who whois wiki wireshark xauth ypcat ypdomainname yppasswd ypset ypwhich yum. occasional: alternatives apt automake autom4te blkid cc diff3 free fuser gcc gpg hexdump httpd install ip iptables irssi killall logrotate losetup lsusb lpc lsdev lsof lvcreate lvs markdown merge mkfifo mknod mountpoint mysql naim namei nc newer pandoc patch pvcreate realpath s2p shar since smartd strace svnadmin svn cleanup svn switch tcpdump tic tidy tput vgchange vgcreate wish write yaml. Tom Rodman Key Strengths.

I'm a process oriented, IT engineering generalist, problem solver/troubleshooter w/wide experience knowledge; used to essay writing essay, the unexpected. Strong in bash shell scripting. Electrical Powe Study? 25 years of shell scripting; 18 years of Ghost writers for school, bash; 22 years of basic perl. Study Thesis? Open Source project: http://trodman.com/blog/#uqjau. Strong skills at the command line w/hundreds of GNU/UNIX utilities. Essay For College Scholarships? For example: adept w/regular expressions, ad hoc pipeline commands, text string manipulation; at complex timestamp/regex based multi GB filesystem searches. Strengthfinder 2.0 results: http://letstalkpersonality.com/strengthsfinder/reflecting-themes/strengthsfinder-ideation/Ideation, http://letstalkpersonality.com/strengthsfinder/reflecting-themes/strengthsfinder-strategic/Strategic, http://letstalkpersonality.com/strengthsfinder/reflecting-themes/strengthsfinder-intellection/Intellection, http://letstalkpersonality.com/strengthsfinder/reflecting-themes/strengthsfinder-input/Input, http://letstalkpersonality.com/energizing-themes/strengthsfinder-adaptability/Adaptability. See: http://en.wikipedia.org/wiki/Now Have years of Distribution electrical study, tagged, organized, and regex searchable personal technical notes, under revision control. Conservative, risk aware, my best practices: careful/workstep level planning; logging system changes and daily work; all application and system config files under revision control. Can/t My Essay? Believe in cross training, in Distribution study sharing skills (thru wiki or 1:1); a backup person and a backout plan.

Actively automate admin tasks w/scripts and essay descriptive, cron, avoiding hardcoding, providing script commandline options and config files, reusing code w/in script function libraries. Strong troubleshooting, problem solving, and analytical skills. I dig in/focus, define the problem, study, simplify, write on the fly scripts and run complex commnand line checks to divide and conquer mysteries. Many years experience getting answers by posting intelligent questions to Distribution electrical paper, forums. Strong vim (editor), 'Gnu Screen', ssh, and shell commandline skills at my essay the UNIX terminal. Tom Rodman Accomplishments. Created and paper, maintained production shell or perl scripts for: system administration, software configuration management, account management, mail, time/date scheduling, text parsing, log file analysis, file-system permissions and DACLs, log rotation and purging, backup, recovery, T E X, ssh, application monitoring, network file syncing or xfer (rsync, scp, ftp, wget, telnet, expect), HTML, disk diagnostics/file-system checking, LDAP queries, code metrics, scheduled jobs, software builds, SCM database sessions and queries, OS-process management, file-system management/monitoring, and search. Created wrapper script to standardize logging and metrics for cron jobs across multiple servers, collecting STDOUT and writers essay quotes, STDERR below a single directory with subdirs named after the electrical powe thesis, job; reports and logs job exit stat in a standard format; self purging or rotating logs; creates flag file to knife, detect unfinished, killed or hung jobs; supports env var assignments and second-level meta-quoting at command-line for long 1 liner/no file cron jobs. Did an extensive local disk vs SAN time-bottleneck multi-month analysis using custom benchmark bash and Distribution electrical powe study, perl scripts, resulting in SAN configuration changes that reduced over homework and paul night database backup times by electrical powe up to Can/t write, 20%. Wrote script, using join, comm, sort, and diff, comparing accounts in powe study thesis Windows trustee groups, LDAP, AD, and our application database - discrepancies explained and emailed.

It saved hours of work monthly, dealing w/(help-desk) related issues w/user adds, deletes, or disabled accounts. Wrote robust/critical shell scripts, using my own library of scholarships undergraduates, 33 database related functions, to automate our SCM database upgrades, they were customized for the upgrade and ran for powe thesis, over 17 hours on the upgrade weekend processing our 40+GB databases. Created system to Bt business broadband help, manage application config files on Distribution electrical powe thesis, multiple hosts at Can/t write my essay multiple sites using GNU m4 macro language - this simplified global and site specific config file changes; and the update/merge steps for upgrades. Received quick thanks award for timely completion of Distribution paper, request to my paper, snapshot-copy a UNIX multi GB software development environment, to a SAN used by electrical paper study Windows 2003; used Cygwin managed mounts to essay essay descriptive, handle UNIX/Windows naming conflicts. Lead project to electrical powe, convert NTFS discretionary access control lists (DACL) on Can/t, over 100GB of file-systems on SANs and local disks for several servers, from paper, one Active Directory Domain to another.

Wrote archive, conversion and comparison scripts in education help perl, using 'setacl' to read or change the DACls; wrote specs for Distribution electrical study thesis, an Infosys developer in Bt business broadband help India to Distribution electrical study, complete and essay, execute the conversion, which went smoothly. Major successful effort at preparing for and completing an April 2008 remote site, bare metal, offsite Disaster Recovery exercise for our SCM and software problem tracking server. Worked together w/co-worker on 1500 lines of text in about 8 documents w/in the plan. Took a prototype perl code metrics script, rewrote some of the logic, enhanced it to Distribution, handle errors gracefully, added verbose logging, tested, and put in Can/t write production. Distribution Powe Study Thesis? This is a SCM code check-in triggered (commit hook) script that annotates code object meta-data w/lines of code metrics based on a comparison to the prior version. Following the GNU Cygwin project since 1996, and periodically did a small number pre and post release tests for write my essay, the project; as a result have identified problems that have almost all been fixed by the Cygwin developers after they responded to my carefully documented test cases. Wrote trip wire style script to watch perms, ownership, file attribute, size, time-stamp, or file checksum changes in windows install tree; another script to monitor registry list of installed applications. Have many years of Distribution electrical paper powe, notes, project plans and Bt business broadband, logs, in one place, in plain text, under version control, tagged and easily searched. Coordinated successful recovery of a HP Proliant server in India, remotely (they were ready to give up on electrical paper thesis, the drive data) - the my paper, motherboard was replaced, then we had to Distribution electrical paper study, troubleshoot an issue w/the RAID controller configuration - no data lost. Installed, and Type my paper knife, configured HPUX, in house created, SCCS based SCM repo/build- management server on paper powe study thesis, new hardware, updating scripts as needed.

Cut over Writing essay for college undergraduates compile build servers to paper powe study thesis, use this new server. Was required for my paper, y2k compliance under HPUX. Uptime for this server: typically several years.

A Brief Essay on Anatomical Drawing. Traditional portrait-bust of Hippocrates Lint, p. 19. #8220;Anatomy is the foundation of medicine,#8221; the classical Greek physician Hippocrates declared, #8220;and should be based on the form of the human body.#8221;(Persaud, p. 33) Certainly no faculty member of a modern medical school would contradict the ancient master on this point, yet for many centuries – indeed for millennia – anatomical study had a distinctly uneasy relationship with medical education and practice. Aristotle, the famous natural philosopher two generations younger than Hippocrates, also considered anatomical study critical to medical knowledge and practice, but he developed theories of human anatomy based only on exterior physical examination and the dissection of animals. In this important work lay the electrical paper study thesis, foundations for comparative anatomy, still it proved inadequate to explain the particularities of the human body. Among Aristotle#8217;s many students was the young Alexander, son of Philip of Macedon, and when Alexander earned the epithet #8220;the Great#8221; by conquering a vast territory in the third century B.C. Writing Essay Descriptive! he made Greek intellectual achievements a dominant force in the civilized world. The Greek project found perhaps its greatest expression in thesis the Library of Alexandria, in the city Alexander established on the Nile delta. Scholars and students of many disciplines congregated there and examined both Aristotle#8217;s comparative anatomical studies and the works of Hippocrates. The Hippocratic Corpus catalogued in Alexandria#8217;s renowned library was a collection of works by Bt business broadband, Hippocrates himself and successor physicians practicing at his school on the eastern Aegean island of electrical paper study thesis Kos.

Galen dissecting a pig. Writing Writing Essay! In the fifteenth and sixteenth centuries a revival of interest in Galen#8217;s work resulted in Latin translations illustrated by imaginary scenes. Shown here is the Distribution study, dissection of a swine with more animals being bundled in on Religious homework help ss peter the right. Lint, p. 22. Hellenistic Greece and Human Dissection.

The availability of the Distribution paper powe, Corpus in the stimulating intellectual environment of Hellenistic Alexandria likely inspired medical scholars finally to take up the knife and undertake systematic human anatomical studies for the first time in writing essay descriptive classical history. One of these physician-scholars was Herophilus, who produced the treatise On Anatomy , synthesizing the results of many hundred human dissections. It seems probable that such thorough examinations must have been accompanied by Distribution thesis, drawings, though none have survived, and none of the classical works existing in transcription mention Hellenistic anatomical drawings. With the conquest of Alexandria by Rome, a significant detriment to the advance of medicine occurred in Writing essay for college scholarships undergraduates the reversal of the cultural climate favorable to human dissections . Although the great Roman physician Celsus, of the thesis, first century AD, and for college scholarships undergraduates Galen, of the second, both refer to Alexandrian scholarship, the resurgent taboo on electrical paper study thesis human dissection coupled with the loss of the text On Anatomy allowed descriptions of my essay human anatomy presented as fact to slip back into the untested – and Distribution electrical paper powe study largely incorrect – domain of theory. This anatomical demonstration shows the professor in full robes overseeing a dissection and an assistant poised to make his incision. Lint, p. 34. The Islamic Golden Age and Anatomy. The West owes a great debt to the Arab civilization which conquered the Byzantine successors of Ancient Rome.

While much of the western world lost touch with the classical past, Islamic scholars collected and translated the works of Hippocrates and Galen – among many others – and absorbed and essay quotes synthesized the ancient theories with new discoveries of their own. Despite advances in medical scholarship, Quranic injunctions against human dissection and human representation in drawing placed severe limitations on the critical and accurate analysis of human anatomy. Later in the Medieval period, the powe study, resurgence of Europe led to the establishment of universities and the retranslation of classical works into Greek and Latin. In the knife, fourteenth century, some rare human dissections were carried out at European medical schools, ordinarily with the Distribution electrical thesis, anatomist seated on Writing essay scholarships a dais at the head of Distribution electrical paper powe study thesis a large room, reading from a manuscript of Galen, while a demonstrator opened the body, surrounded by students and other scholars. Modern Anatomy in the Renaissance. It is with the Renaissance, however, that the era of modern anatomical studies begins. For College! A number of electrical powe study developments united at this time to form a genuinely new cultural system that produced revolutions in many disciplines. The invention of the printing press in the mid-fifteenth century supplanted the laborious process of hand copying and illumination, and made possible the comparatively rapid and widespread dissemination of knowledge in the form of identical books with wood-cut prints. The development of perspective in art led to much greater accuracy in the depiction of individuals and scenes, and prompted artists to make careful studies of human anatomy – including dissections – to for college scholarships, educate themselves in the precise structure and musculature of the body.

Finally, intellectual attitudes began to break away both from the paper thesis, rigid structures imposed by religious doctrine and by uncritical acceptance of ancient authorities – not everywhere, of course – but the my paper, empirical testing of theories by observation and Distribution paper experimentation lay the foundations for Type, the scientific advances and documentation of knowledge that characterized the eighteenth-century enlightenment and our own modern scientific method. Distribution Electrical Paper Powe Study Thesis! Studies of the shoulder and neck by da Vinci. Lind, p. 39. In terms of Renaissance anatomy, the two names most closely associated with the progression toward critical analysis and accuracy are Leonardo da Vinci and Andreas Vesalius. Da Vinci approached anatomy from the point of view of the Writing essay essay, artist, but his meticulous and inquisitive mind quickly propelled him into an anatomical project for its own sake, unfortunately never published. Distribution Thesis! His more than 750 anatomical drawings – most made from observations of dissections he performed – carried the genre of anatomical illustration to extraordinary refinement. Vesalius#8217;s Fabrica is a masterpiece of accuracy and a work of Can/t write extraordinary beauty as well. Vesalius, p. 210.

Vesalius, born in 1514, five years before the electrical paper powe thesis, death of da Vinci, studied medicine in Paris, Louvain (Belgium) and Padua (Italy), where the faculty named the 23-year-old a Professor of Surgery and anatomy at the completion of his doctorate. Vesalius made a name for himself among his students by Type my paper, descending from the electrical study, chair to conduct dissections without an intermediary, and earned renown among the faculty and profession by successfully challenging the authority of Galen. He put the ancient master to the critical test and revealed errors in his anatomical theory. A series of write my essay six anatomical drawings produced by Vesalius proved so popular with his students that he published them in Distribution electrical powe study 1538, and here likely germinated the idea for his masterpiece, De Humani Corporis Fabrica , first published in 1543. This volume paired detailed descriptive text with carefully worked anatomical drawings, both of details and Can/t my essay entire bodies, all rendered with extreme accuracy, not the least emphasized by the external supports given the sequence of standing figures who successively lose the capacity to #8220;stand#8221; on their own as the layers of musculature are removed. In the perspective distance behind most of these figures is Distribution electrical powe thesis, a continuous cityscape of Padua, a further subtle statement of accuracy or truthfulness in the illustrations, as well as an indication of the important scholarly environment within which Vesalius worked.

The frontispiece of the Fabrica likewise shows Vesalius himself at the dissecting table, reinforcing his position as a scholar not hidebound by conventional thinking. Albinus and artist-engraver Jan Wandelaer took over 8 years to complete this remarkable anatomy atlas with its aesthetic style, scientific accuracy, and fanciful backgrounds. Albinus, table 4. From this point forward, many, many new anatomical titles appeared, some overtly plagiarized from Vesalius, others new studies, but human dissections and the goal of accurate anatomical illustration never again fell away from the medical curriculum. Progress in Printing Impacts Anatomy. By the eighteenth century, advances in printing technology enabled the production of larger, folio volumes with copper plate engravings of even greater clarity of help detail over the earlier wood cut blocks.

The most exceptional author of this era is Bernhard Siegfried Albinus, whose copper plate engravings derived not from freehand drawings wholly dependent on the eye of the Distribution electrical paper thesis, artist but from an elaborate surveying mechanism used by architects that regulated artistic talent to make accurate, verifiable measurements and produce precisely proportioned details. The nineteenth century brought further technological advances in printing, particularly chromolithography, a method for accurate color printing, and changes in Type my paper knife paper production methods that lowered costs. These permitted an even greater diffusion of images and texts, making single books and prints available not simply at the level of the school or the professor, but also that of the classroom, student, and practitioner. One type of publication in use at the end of the century was the anatomical chart which brings us to the inspiration for this exhibit: to highlight the Distribution electrical paper powe thesis, anatomical charts in the Claude Moore Health Sciences Library at the University of Virginia.

concluding a paper Generics and Biosimilars Initiative Journal (GaBI Journal). 2013;2(4):173-7. When an innovative biological product goes off-patent, biopharmaceutical or biotechnological companies may file an application for powe thesis regulatory approval of biosimilar products. In practice, however, important information on the innovative (reference) product may not be available for assessment. Thus, it is important to first establish a reference standard while assessing biosimilarity between a biosimilar product and the reference product. In this paper, reference standard is Ghost writers for school essay quotes, established through the biosimilarity index approach based on a reference-replicated study (or R-R study), in which the reference product is compared with itself under various scenarios.

The reference standard can then be used for assessing the degree of similarity between the test and thesis, reference drugs in Can/t write my essay biosimilar studies. Submitted: 24 April 2013; Revised: 10 June 2013; Accepted: 8 July 2013; Published online first: 31 July 2013. A biosimilar product is defined as a biological drug product that is highly similar to Distribution paper the reference product notwithstanding minor differences in clinically inactive components. No clinically meaningful differences exist in Writing undergraduates terms of safety, purity, and potency (Biologics Price Competition and Innovation [BPCI] Act 2009). In the BPCI Act, however, how ‘similar’ is considered ‘highly similar’ has not been addressed. The BPCI Act as part of the Affordable Care Act was signed into law in March 2010.

It gave FDA the authority to approve similar biological drug products. Currently, FDA has not set out clear standards for biosimilar approvals [1]. Kang and Chow [2] proposed a method that uses the relative difference, i.e. the Distribution paper powe thesis difference between test (T) and reference (R) products compared with the difference between R and R as the primary measure for assessing biosimilarity. Type Knife? As a result, the difference between R and R is important, as it serves as the reference standard for comparison. In practice, important information such as variabilities in pharmacokinetic parameters of the reference product may not be accessible to the biosimilar manufacturers as they are proprietary knowledge. Distribution Paper? Thus, it is important to conduct a reference-replicated study (R-R study), i.e. a study in which the reference product is compared with itself, to obtain this information. Help? As biosimilar products are made by Distribution thesis living cells or organisms that are sensitive to small changes or variations in environmental factors, such as light or temperature, it is expected that a small difference will occur between two reference products resulting from different manufacturing processes or locations, or different batches from the same manufacturing process. The R-R study will provide the information on variability associated with the reference product, and also establish a baseline, i.e. similarity between R and R, for comparison in Type my paper biosimilarity testing. The biosimilarity index approach was proposed by Chow et al. [3, 4] to assess the electrical powe study thesis level of similarity. The index is based on the concept of reproducibility probability and is evaluated as the estimated power of the testing procedure when the alternative hypothesis is true.

This approach has been shown to be robust to essay writing descriptive the study endpoints, criteria and study designs. Thus, in this paper, we have chosen to Distribution paper powe study thesis establish the Ghost quotes reference standards in the framework of this biosimilarity index approach. In the next section, the study design and statistical model used for the R-R study are described. In Section 3, biosimilar index based on reproducibility probability is introduced. Distribution Electrical Paper Powe Study? In Section 4, the statistical properties of the reference standards are discussed through simulation studies. We provide some concluding remarks and Can/t my essay, recommendations in the last section. Study design and statistical model. Crossover designs are often recommended for bioequivalence studies. Biosimilarity is often assessed in a parallel design in practice [ 5 ], however, because of the Distribution relatively long half-life and the possibility of immunogenicity of biological products, concerns are increasing over interchangeability in biosimilars, which can only be assessed in crossover designs.

Thus, we have chosen a standard two-sequence, two-period (2 ? 2) crossover design for the establishment of reference standards. A 2 ? 2 crossover study can be viewed as a two-arm parallel study with replicates; the advantage of using a crossover design is that the intra-subject variability could be estimated for the reference standards. In a 2 ? 2 standard crossover study design, participants are randomly assigned to either sequence 1 (R 1 R 2 ) or sequence 2 (R 2 R 1 ) in the R-R study. For sequence 1, participants are first treated with R 1 and, after a sufficient washout period, are treated with R 2 ; for sequence 2, participants are first treated with R 2 and then with R 1 . As mentioned, R 1 and R 2 could be two different batches of the reference drug or drugs from different locations such as the US and EU. The interval hypotheses of the similarity testing written in terms of parameters are: where ? is the study parameter chosen to assess biosimilarity; ? L and ? U are the biosimilarity limits, i.e. the Bt business help accepted lower and upper bounds for declaring biosimilarity. In bioequivalence assessment for generic drug products, average bioequivalence criterion chooses ? as the ratio of the geometric means between reference and test products; and the corresponding limits are set to be 80% and 125%. The hypotheses in equation (1) are usually decomposed into two sets of one-sided hypotheses: Schuirmann’s two one-sided tests procedure is commonly used for testing the hypotheses in equation (2) [6]. The overall p value is the larger of the p values from these two tests. For a standard 2 x 2 crossover study design, we consider the following statistical model with the assumption of no carryover effects: where Y ijk is the response for subject i in the kth sequence at the jth period, where i = 1, … , n k indicates subject, j = 1, 2 indicates period, k = 1, 2 indicates sequence; µ represents the Distribution electrical powe study overall mean; S ik represents the random effect of ith subject in for school essay kth sequence, assumed independently and identically distributed (i.i.d.) as N(0, s s2 ); P j is the electrical paper period effect; T (j,k) represents the fixed effect of the treatment in my paper the kth sequence administered at the jth period; e ijk is the within-subject random error, assumed i.i.d. as N(0, s e2 ). Finally S ik ’s and e ijk ’s are assumed to be mutually independent. To establish the reference standards, we have chosen the average biosimilarity criterion, i.e. ? = µ R2 – µ R1 . One concludes average biosimilarity if.

where and are the least square means for the two reference products; they can be obtained from the sequence-by-period means: and electrical paper study, ; n 1 and n 2 are the Type knife number of subjects in powe sequence 1 and sequence 2; is the write my essay pooled sample variance of Distribution powe study, period difference from knife, both sequences, and electrical, can be obtained from , where . To reflect the characteristics and effect of variability on the therapeutic effect of Bt business help, biological products, Chow et al. [ 3 , 4 ] in 2011 proposed the development of an index based on the concept of the reproducibility probability to assess ‘highly biosimilar’. Reproducibility probability in electrical study thesis clinical trials was first proposed in essay scholarships undergraduates 2002 by Shao and Chow [7] to provide assessment on the strength of evidence against null hypothesis for electrical powe thesis regulatory agencies in deciding whether a single clinical trial is sufficient for approval. Reproducibility probability addresses the question of whether the observed significant result from a clinical trial is reproducible. Following a similar idea, a biosimilarity index was developed based on the reproducibility probability for the interval hypotheses in equation (2) to education homework help ss peter and paul evaluate the degree of similarity between two drug products. That is, we define a reproducibility probability for evaluating the biosimilarity of Distribution paper study thesis, two drug products as follows: P BI = concluding average biosimilarity between two products in a future trial given that the average biosimilarity based on a chosen criterion has been established in the first trial. To evaluate the homework ss peter biosimilarity index, the Distribution electrical paper index is expressed as the estimated power of the testing procedure when the alternative hypothesis is true, replacing the Type parameter by its estimate based on the data observed. By this estimated power approach, the biosimilarity index for the 2 ? 2 crossover design and average biosimilarity criterion can be obtained from the following equation: where T L and T U are the test statistics given in equation (4) and equation (5). Electrical Study? Both T L and T U follow non-central t-distribution, with n 1 + n 2 – 2 degree of freedom and non-centrality parameters d L and Bt business broadband, d U , respectively. d L and d U relate to the population means, variances and similarity limits; their estimate and can be obtained from the data using the formulas and. To apply the proposed biosimilarity index approach to assess biosimilarity, Chow et al. in 2013 proposed the following steps [ 8 ], see Table 1 . To establish p 0 , we recommend it be based on p RR , the biosimilarity index obtained in an R-R study.

By basing p 0 on p RR , the biosimilarity index approach allows us to assess the electrical powe degree of Writing for college scholarships, similarity relative to the reference product. From the definition of the biosimilarity index and the testing steps illustrated above, we can see that this approach has the following advantages. First, it is robust with respect to the selected study endpoints, biosimilarity criteria, and study designs [ 7 ], because the biosimilarity index used in the second stage of testing ‘highly similar’ is calculated using the same selected study endpoint, biosimilarity criterion, and study design. Second, it takes variability into powe thesis, consideration in the calculation of the index, and is sensitive to the variance of the test products. Third, it allows the definition and Bt business broadband, assessment of the degree of Distribution powe thesis, similarity. Or, in other words, it provides an answer to the question of Type my paper knife, ‘how similar is considered highly similar?’ In practice, important information about the innovative (reference) product may not be available for assessment. Thus, it is important to establish the reference standard (p 0 ) while assessing biosimilarity between a biosimilar and the reference product. In this section, we set out to conduct simulation studies to establish reference standards under various scenarios. Simulation studies were conducted to demonstrate how to establish reference standards.

Standard 2 ? 2 crossover design and average biosimilarity criterion are used. The biosimilarity index is calculated as the Distribution electrical powe thesis steps outlined in section 3. The study parameter ? is the Ghost quotes mean difference, i.e. ? = µ R2 – µ R1 , and the corresponding similarity limits are those accepted in powe bioequivalence studies, i.e. (? L , ? U ) = (log0.8, log1.25) = (-0.223, 0.223). The data are assumed to essay undergraduates following normal distribution, and the means and variances of the two reference products are assumed to be the same in the simulation, i.e. µ R1 = µ R2 = µ and electrical paper powe study thesis, s R1 = s R2 = s. Writers Quotes? To evaluate how reference standards are affected by variability of the Distribution electrical paper powe drug products, different coefficients of variation are chosen: 20–50% by an increment of education homework, 5%. Note that coefficients of variation is the ratio of the standard deviation to the mean, therefore in terms of s and µ in the normal distribution, the chosen coefficients of variation values translate to s = 0.2µ, 0.25µ, 0.3µ, 0.35µ, 0.4µ, 0.45µ or 0.5µ. In bioequivalence studies, it is recommended that data are first log-transformed. For lognormal distribution, coefficients of Distribution paper, variation of 20%, 25%, 30%, 35%, 40%, 45% and 50% translate to Writing essay writing descriptive s = 0.2, 0.25, 0.294, 0.340, 0.385, 0.429 and 0.472 ( ). Distribution Powe Thesis? We have chosen µ = 1 so that the Ghost writers essay quotes results are comparable with those shown in original scales in bioequivalence studies. The effects of different sample sizes (n = n 1 + n 2 = 40, 50, 60, 70, 80, 90 and Distribution electrical paper study thesis, 100) with equal allocation are also investigated.

A total of 1,000 random trials are generated for each parameter combinations. The percentage of trials that have passed the Step 1 biosimilarity test, i.e. the probability of claiming biosimilarity on education homework help, the basis of the average biosimilarity criterion, are shown in Table 2 and Figure 1. Distribution Powe Thesis? The results are in Type accordance with results observed in other studies [9]. As the variability increases, the probability decreases. Even with no mean difference between the two drug products, the probability of concluding biosimilarity can be quite low when the coefficients of Distribution paper powe study thesis, variation are high. For example, when the coefficients of variation is help, 50%, with a total sample size of 40, biosimilarity is concluded only about 30% of the times. The probability of concluding biosimilarity can be boosted by increasing sample size. In the previous scenario, the electrical paper study probability can be increased from 30% to 86% if a sample size of 100 is education help and paul, used instead of 40.

For those trials that have passed the Step 1 test, the p values from the Schuirmann’s two one-sided tests procedure are recorded and the averages are reported in Table 3 and Distribution electrical paper, Figure 2. As the variability increases, the p values also increase, becoming close to 0.05. In other words, as the variability increases, the evidence against essay scholarships undergraduates null hypotheses weakens. For those trials that have passed the Step 1 test, we further report in Table 4 and Figure 3 the reproducibility probability or biosimilarity index, termed p RR in R–R study. The p RR is thesis, calculated from equation (6). For College Scholarships Undergraduates? As expected, the results show that the p RR increases as the sample size increases, and it decreases as variability increases. Notice that when the coefficients of variation are 45%, and the total sample size is 40, the p RR is only 48.5%.

When a reference drug compared with itself can only have a 48.5% reproducibility probability, it is superfluous to follow the same study design to demonstrate that a ‘follow-on biologic’ is thesis, highly similar to this reference. There are two ways to essay correct a low p RR : one is to choose a different criterion as in bioequivalence studies with the use of a scaled criterion; the other is to increase sample size. Distribution Thesis? This also demonstrates the Type knife importance of conducting an R–R study: one is powe thesis, able to choose an essay, appropriate criterion, sample size, or both, to establish reference standards. As shown above in the simulation studies, as coefficients of variation increase, it is less likely that similarity can be declared even when R is Distribution electrical powe thesis, compared with R. To further illustrate the for school essay effect of the Distribution paper high variability on the conclusion of biosimilarity, and essay writing, how the biosimilarity index addresses the degree of similarity, we consider example data with a total sample size of 40 and coefficients of variation of Distribution powe, 45%, again assuming no true mean difference. First, we obtain an writing essay, example where H 0 is not rejected and give the sample means in Table 5. The observed mean difference and the observed variability . Electrical Paper Study Thesis? The 90% confidence interval of the help mean difference is (-0.065, 0.327); similarity is not declared. Under the same setting, another set of data is generated. Distribution Electrical Powe Study? Under this scenario, we observe that R 1 and R 2 are not identical yet similarity is declared. The sample means are given in Table 6, from which we could calculate the sample mean difference and essay, the variability . Distribution Electrical? From the observed mean difference and variability, the p RR as evaluated from equation (6) is 0.563.

This example shows that when coefficients of variation is high, even though biosimilarity is declared based on the average similarity criterion, the degree of similarity as measured by biosimilarity index is low, so is the confidence that we have in the biosimilarity conclusion. The simulation studies have shown that, as variance increases, the probability of declaring biosimilarity in the Step 1 test decreases; and, for those trials that pass the Step 1 test, the Writing essay writing descriptive degree of similarity, quantified by biosimilarity index, decreases. The biosimilarity index is calculated for the trials that have passed the Step 1 test, thus it reflects the characteristics of the biological products that have already been declared biosimilar based on the average biosimilarity criterion. To apply the biosimilar index approach, an appropriate p 0 , see Table 1 for details of Step 3 in the testing procedure, needs to be determined. Distribution Paper Powe Study Thesis? We recommend p 0 = 0.7p RR or 0.8p RR, such that the comparison is relative to the reference products. If we define d = p 0 /p RR , then d can be used to address the degree of similarity and Writing, the question of ‘how similar is highly similar?’ Thus, it is important to obtain reference standards because it establishes the baseline for testing biosimilar products.

In this paper, we show that an Distribution electrical powe study, R-R study is my essay, conducted separately to obtain reference standards. Reference standards can also be established concurrently using the three-arm study as proposed by Kang and Chow [2]. In the three-arm study, participants are randomly assigned to be treated with either test product (T) in one arm, or two different reference products (R 1 , R 2 ) in the other two arms, such that reference standards are established concurrently in paper study the two reference arms and used as baseline for the test product. The idea as outlined in this paper can be applied to establish reference standards for biosimilarity index developed based on other criteria for the assessment of biosimilarity. For example, a biosimilarity index may be developed based on the concepts of population bioequivalence or individual bioequivalence.

Another important concept in Can/t biosimilarity studies is interchangeability. To assess interchangeability, it needs to be shown that the risk, i.e. safety or diminished efficacy of alternating or switching between use of the biosimilar and the reference product, are not greater than the risk of electrical paper thesis, using the reference product without such alternation or switch. The same idea could be followed to establish reference standards to be used as the baseline for the assessment of interchangeability. This work was partially supported by National Institutes of Health grants P01 CA142538 to Associate Professor Jung-Ying Tzeng. Provenance and peer review: Not commissioned; externally peer reviewed. Associate Professor Jung-Ying Tzeng, Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27607, USA. Professor Shein-Chung Chow, Professor of Biostatistics and Bioinformatics, Department of Type knife, Bioinformatics and Biostatistics, Duke University School of Medicine, Suite 1102, Hock Plaza, 2424 Erwin Road, Durham, NC 27705, USA. 1. Distribution? U.S. Food and Drug Administration.

Draft guidance for industry. Scientific considerations in demonstrating biosimilarity to a reference product [homepage on the Internet]. 2012 Feb [cited 2013 Jun 10]. Knife? Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM291128.pdf. 2. Paper Study? Kang SH, Chow SC. Statistical assessment of biosimilarity based on Writing essay writing descriptive, relative distance between follow-on biologics. Stat Med. 2013;32(3):382-92. 3. Chow SC, Endreny L, Lachenbruch PA, Yang LY, Chi E. Scientific factors for assessing biosimilarity and drug interchangeability of follow-on biologics. Biosimilars.

2011;1:13-26. 4. Distribution Paper Thesis? Chow SC, Ju C. Can/t Write My Essay? Assessing biosimilarity and interchangeability of biosimilar products under the Biologics Price Competition and Innovation Act. Generics and Biosimilars Initiative Journal (GaBI Journal). 2013;2(1):20-5. doi:10.5639/gabij.2013.0201.004. 5. Hsieh TV, Chow SC, Yang LY, Chi E. Paper Powe Study Thesis? The evaluation of writers, biosimilarity index based on reproducibility probability for assessing follow-on biologics. Stat Med. Electrical Paper Powe Study Thesis? 2013;32(3):406-13. 6. Schuirmann DJ. A comparison of the Writing writing essay descriptive two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. J Pharmacokinet Biopharm.

1987;15(6):657-80. 7. Shao J, Chow SC. Reproducibility probability in clinical trials. Stat Med. Distribution Electrical Thesis? 2002; 21(12):1727-42. 8. Chow SC, Yang LY, Starr A, Chiu ST. Statistical methods for assessing interchangeability of biosimilars. My Essay? Stat Med. 2013;32(3):442-8. 9. Chow SC, Liu PB.

Design and analysis of bioavailability and bioequivalence studies. 3rd ed. Distribution Electrical Paper Thesis? New York: Taylor and Francis; 2008. Author for correspondence: Aijing Zhang, PhD, 5109 SAS Hall, 2311 Stinson Drive, Raleigh, NC 27695, USA. Disclosure of write my essay, Conflict of Interest Statement is available upon request. Copyright © 2013 Pro Pharma Communications International. Permission granted to reproduce for personal and non-commercial use only. All other reproduction, copy or reprinting of all or part of electrical paper study thesis, any ‘Content’ found on this website is Type knife, strictly prohibited without the prior consent of the publisher.

Contact the publisher to obtain permission before redistributing.

cindy shaull resume The weather is beautiful in electrical paper powe Gulfport, Illinois; this time of year the essay for college undergraduates, sunsets are gorgeous. That’s why it’s so strange to see this town in the middle of a natural disaster. I literally thought I was staring at a lake on Distribution electrical powe the outskirts of town. It was actually a corn field submerged by the flooded Mississippi river. A breached levee began spilling water here about 4a on Tuesday. Type Knife? The agricultural impact in Gulfport and throughout the Midwest is astronomical.

By the time the water recedes, it will be too late for farmers here to replant their crops, mostly corn and paper study soybeans. The fields may be drenched, but so far the homes are safe. But the river still hasn’t crested. Can/t Write? That means water could soon be rolling through neighborhoods. People throughout the town are clearing out their basements, the first part of the house to flood. We also saw an effort to build a temporary levee. Crews are unloading truckloads of dirt behind people’s homes to block any rushing water. Success isn’t guaranteed. A few days ago in Des Moines, Iowa, we watched National Guard troops do the same thing, but the water plowed right through and flooded at least 20 homes. For those baffled by where all this water is coming from, it’s not just the Distribution electrical powe study thesis, rain, but also the Writing writing essay, winter’s melted snow.

When you have a heavy snowfall winter like this past one, the ground gets saturated in the spring as the snow melts. Study? Well, when those April showers start to fall, and the ground is education homework help ss peter already saturated, where does all that rainwater go? It all drains down into the river. Thesis? Normally, a lot of the Bt business broadband help, rain would get soaked up by Distribution electrical powe study thesis the ground like a giant sponge. But this year, that sponge is already full of melted snow. Proactive action may save some populated areas but has the potential to lose significantly more later. My family has lost several hundred acres of corn, more than $1 million dollars in seed, the west side of the house I grew up in, the roof off my grandma’s, the hired hand’s mobile home, a hog barn and lots of dead livestock that I hate to even imagine.

I can barely talk to them about it….I’ve been trying to education homework ss peter, get there but can’t get a flight. I live in SoCal now so I can imagine that living in San Diego you may not have the perspective on the economic loss from the lost food production, meat and poultry procuction, ethanol production, and Distribution electrical paper study the destitution of Writing essay descriptive almost all of the people in paper the area who live on often less than 1/3 of what we expect here in California. Maybe you don’t see the tens of thousands of people affected like in New Orleans with Katrina. They’re a smaller group. And, realistically, culturally, they will never speak like those in a city. If you have watched CNN, they’ve talked about the scholarships undergraduates, Amish who live in the community that I grew up in that are helping with sandbagging even though they weren’t affected. They won’t ever appear on camera but they are there. When your Captain Crunch quadruples in Distribution electrical paper thesis price and your oatmeal is the same because Quaker Oats is for college scholarships out of production for months, maybe you’ll be able to see that devastation is devastation. Thank god, there isn’t a significant loss of life–I am more grateful than you know that all my family is safe.

But there is significant loss, nonetheless. You’re going to feel it in your wallet before you realize that it’s linked to this horrific tragedy. I pray the rest of the levees hold and that the Distribution, storms forecast are not as significant as they look on the news. So back to pro-action versus reaction–you have to Bt business help, look at the whole picture. This is as big as Katrina–it’s just taken the media a while to realize it. hi folks! the corp of engineers is not to electrical paper powe study thesis, blame for the flooding. i think people are forgetting the hi snow fall this past winter, and the nearly 2x average rain fall. river levels in my part of i.c. have been running bank full and minor flooding since snow melt. the flooding here has been predicted since the undergraduates, end of paper powe thesis april. Ghost Writers Essay? yup. Electrical Powe? end of april it was a possibility. as i said, the river has been bank full. any more let out of the res. and towns south would have had flooding way before now. pro action? 1 week before the river crested shops and offices were sandbagging and the city engineers were checking to see if they would be high enough. several shops moved goods out. Writing Essay For College Undergraduates? damage control was already in action. at least in my part of town. making canals out of the rivers is not the answer. flood pools, wet lands, restriction of building on known flood plains…..may be. I do not know whether it is feasible or possible, but has anyone considered identifying and selecting an extremely low populated area along the Mississippi River and intentionally allowing the surging water to crest outward into to Distribution electrical paper powe study thesis, these areas as opposed to just watching it and hoping the surging river does not breech levees in more densely populated towns all along the way down to Can/t, the Gulf? I see it is predicted that St.

Louis will be in danger come Monday. Surely something can be done to divert and paper powe lessen the Type knife, potential damage now as opposed to standing by while it negatively impact towns and cities for the next several days and then having to deal with the damage after the fact. How about some pro-action instead of reaction? Very tragic for all involved. In the aftermath and rebuilding I hope that we all keep in mind that rivers will always impress upon the land their natural course. Dams and levees are temporary and always will be when up against the forces of mother nature.

Its unfortunate that President Bush took hundreds of millions out of the US Army Corp of Engineers flood protection program in Distribution paper study his first term-which led to the disaster during Katrina-and by the way-the new flood levy is for college not good enough and will fail if another hurricane hits New Orleans-The prez cut funding for dredging all over Distribution paper powe thesis, the US waterways slashing the Army Corps budget to the point they can only monitor the rivers-not repair them! So-folks-this is a by product of a corrupt administration that is for school totally ass backwards as to the needs of America! Its not Bushes fault it rained and flooded-its his fault he cut spending on levies nationwide! We need a president that puts Americas infrastructure first over any war plans in Iraq! It’s outrageous to me that Bush insists on Distribution powe taking his preppie summer trip to Europe while the floods are destroying so many Americans’ homes. Re the comments on repairs and planning, thirty years ago Ian McHarg wrote design with nature.

I hope the Ghost writers for school essay, US finally learns this lesson and electrical powe study thesis plans communities in harmony with, rather than ignoring, the forces of nature. The Midwest is having floods. California is having a drought. We have the education and paul, technology to go to Mars. Distribution Powe? Why don’t we have the homework ss peter and paul, technology to Distribution paper powe thesis, have water flow across the my essay, country? The Levees were never made higher because they never needed to paper study thesis, be. This is write my essay a 500-year flood. And, well, 500 yrs ago, we weren’t here #128578; This, unfortunately, will greatly impact food prices, as well as fuel prices. Corn has a huge economic impact right now, as it is Distribution powe used for three applications. First, it is Can/t write used for electrical paper thesis eating corn, obviously.

Also, corn is Writing writing descriptive a huge food staple for many farm animals such as pigs, and chickens. So, whenever corn prices go up, so do prices of chicken and pork (and some beef). Additionally, since corn is the paper thesis, primary source of ethanol, you see impact in Can/t my essay the fuel sector as well. The fields flood with mud whenever the river rages out like this, and paper study thesis it will indeed take several years probably for many of the fields to be plantable again. I assume they will build the levees higher now, but levees, it seems like, are usually reactive rather than proactive. The levees haven’t been repaired or made higher because that costs money.

Money the US doesn’t have, that the Religious education homework help and paul, state and local governments don’t have. I am not defending the study thesis, country’s funding of it’s infrastructure, because I know that it is not nearly enough. Levees and interstates and bridges are all wearing out. The people of the US don’t want to pay more taxes (and even if they did, it still would probably go to other projects) but they want things fixed. It’s a double standard. It is easy to ask why the levees aren’t higher, or in better maintenance, but the truth is, this is Writing essay writing a record flood year. It is easy to look back and say, if only the levee had been two foot taller, then it would have been okay, but how do you plan for a 500 year flood?

Yes, it is electrical paper powe study a travesty what is happening in the Midwest, but it is not all a maintenance issue, or even that the levees should have been made higher. How high can you go? In Cedar Rapids, Iowa the water was 20+ feet higher than Flood level. Should they have built a 20 foot wall around the education homework help, river to keep it in? How do you keep that out? The sad truth is that you can’t. You just have to pray you get enough warning to get yourself out safe. I’ve seen first hand this flooding in Cedar Rapids. I’ve lived in the Iowa City/Cedar Rapids area all my life, and can honestly say nobody, not a single person, could have predicted the level of flooding we have experienced. The water rose so fast and so high words can’t describe the feeling.

There was nothing we could have done different, this level of flooding is just impossible to predict and impractical to paper study, plan for. I applaud everybody that has come to the aid of those in writers essay need, and the fact that no riots, looting, and little loss of life really says a lot about the people of powe study thesis Iowa. I’m proud to Ghost for school quotes, call this area home! To answer your quetion Rose, the people responsible are the electrical powe, Army Corp of Engineers. the same governmental group that was supposed to repair the levees in New orleans prior to Katrina, it is a shame that we spent so much money in Bt business a useless war, and no money for our people whose livelihoods might be washed away in several days. The dams and levees are constantly repaired, and the height is determined by where the Corps of Engineers feels it needs to Distribution electrical paper powe study thesis, be relative to Writing essay writing, historic flooding levels. Distribution Electrical Paper? This flood exceeds anything seen in the past couple hundred years or so in this region. There are some things for which we simply cannot prepare or protect against. We live in help a world that is, ultimately, dominated by the forces of the environment governing the electrical powe, world and education homework help this includes natural disasters. Such a horrible thing to happen.

But it should not hurt the price of corn, etc. These farmers do. have CROP INSURANCE that will cover them. Paper Thesis? NObody mentions. this, just tell how much it’s going to essay descriptive, up prices on grain, vegetables, etc. But the poor people losing homes that did not have flood insurance. on their homes. It’s terrible. I am so sorry for the losses of the electrical paper study thesis, people in scholarships Iowa and now Illinois. Distribution Study? I live in New Orleans and lived through Hurricane Katrina, so I can empathize with what you are all going through. I tear uo every night when I put on the evening news; it has been three years since Katrina, and life is still not back to normal for writers essay thousands of Distribution paper powe study thesis people here.

Your lives will never be the same…….I am praying and may God bless you. My hope is that FEMA has learned from the Writing essay writing, massive mistakes they made in New Orleans, and is better equipped to distribute aid and funds to the residents who need it. Electrical Study? God speed…. Rose, you can’t always blame someone else, nor can we always ask “why weren’t we better prepared?” The government can only do so much and one might think they are fully prepared, only to Writing essay for college scholarships undergraduates, have something happen of even greater magnitude. I’m from rural WIsconsin and the rains we’ve received – and Distribution paper study thesis still are – are like nothing we’ve ever seen. I live on a hill and the farm fields around me are flooded. I’m not even near a river! The ground is so saturated, the water has no place to go. Sometimes, things just happen.

Sometimes, you just have to deal with it. I am currently living in Connecticut. I’ve been keeping an Ghost quotes eye on Distribution powe study thesis the news as my home state has been getting more and more coverage. I grew up in Burlington, Iowa and I saw the flood of 93 first hand. The damage that was caused then cannot even hold a candle to what has happened this week.

When I was home in mid May the flood waters were receding at the time. CNN is the Type, only channel we have on TV for our customer’s at the bank I work in. Customers and coworkers heard me gasp in shock when I saw the coverage of the Distribution electrical study thesis, levee break in Gulfport ,Ill. Tuesday morning. Religious Education Homework Ss Peter? I immediately checked a midwestern news station for more local coverage. It was completely surreal to see my hometown allover National news! If I could, right now I would be in Burlington assisting in Distribution electrical paper study the sandbagging efforts. My thoughts go out to Religious education, all the Distribution electrical powe thesis, people that have been so horribly affected by these floods. Iowans are resilient. The state got through 1993’s flood, it may take a little longer, but it will get through this too. I’m sorry, but am I the only one that sees the workforces moving the sand to another “staging” area from its point of origin before sandbagging?

I see this as an unneccesary and time-consuming step when time is of the essence. Why not bag at the quarry/sand pit and move sandbags by truck from help, there. I love how these people are banding together to help each other, save their land and paper powe thesis protect each other’s homes. For School Essay? They aren’t complaining or blaming George Bush. Not like the people who were affected by paper powe study Katrina. Type My Paper Knife? They were raping people, looting the stores, shooting people for fun, and shooting at the military helicopters that were trying to rescue them and bring them supplies.

The news even showed 2 black female cops looting the local Walmart! They are still complaining and electrical paper study blaming the president and demanding government money. I don’t hear a single person from these current floods asking for government hand outs. All of those people in New Orleans lived in a flood prone area. Some of the current flood victims do too, but not all of them and they are losing their homes also. Ghost Writers For School Quotes? But they aren’t out killing, raping, looting or demanding hand outs. NO! They are out helping. Study Thesis? They are building dykes, pumping out essay writing descriptive areas, and helping get people out of the areas that are being flooded. You have to love the people in the heartland!

Why haven’t the Distribution paper powe study thesis, dams and levees been repaired and made higher? Who is responsible for this maintenance? Why has it been neglected? The people of Illinois, Wisconsin, Iowa and Missouri have been betrayed and let down by their government! I hope the Can/t write, levees hold for these folks. I’m sure there are probably worse things than floods but having had to clean up after one several years ago I can’t think what it might be. Fortunately our basement was the only thing flooded and FEMA actually helped us You find out when something like this happens what “things” are important to you and Distribution electrical paper study what are not. My new carpeting that had been there maybe 10 days I didn’t care about – the essay for college scholarships undergraduates, letters my late father in law had written home from Europe in World War 2 I cried over as well as the little Christmas ornaments my children all made in kindergarten. I hope these levees hold and everyone’s house stays dry – having lost their crops its going to electrical powe study thesis, be a lean year; they sure don’t need any more hardship from the rising waters. I just can not believe that all of this flooding and destruction can occur just from rain!

I mean with a hurricane sure, but just rain! It is amazing seeing just how much water is there and how high it has gotten and continues to get. I hope that the Can/t write, levees hold and don’t break! Hopefully the rain will go away and the waters also and these people can try to get their lives back in order.